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Figure 2 | Genetic Vaccines and Therapy

Figure 2

From: Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas

Figure 2

Comparison of sizes and fluorescence signal intensities in the original tumor sample for "lost" and "recovered" transcripts. A. The sizes of transcripts Present in tumor's total RNA and reported as Present (PP) or Absent (PA) in the cRNA library of MEL02 and MEL10 patients were plotted. The average size of "recovered" genes was significantly lower (t test, P < 0.0001) than the average size of "lost" genes. B. The fluorescence signals of genes "Present" in the original tumor were compared for the transcripts reported as Present (PP) or Absent (PA) in the corresponding mRNA libraries. The group of "recovered" genes showed a significantly higher (t test, P < 0.0001) mean signal than the group of genes "lost" during the library production.

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Genetic Vaccines and Therapy

ISSN: 1479-0556