Formulationsa | Miceb | Guine-pigsb |
---|
No vaccination | 74 ± 8 | 69 ± 9 |
BCG | 18 ± 5* | 24 ± 4* |
DNAv (naked DNA) | 72 ± 9 | 65 ± 7 |
DNAhsp65 (naked DNA) | 38 ± 7* | 42 ± 6* |
Me-DNAhsp65/TDM | 41 ± 6* | 40 ± 7* |
Me-Prime/boost | 37 ± 5* | 38 ± 6* |
- aMice and guinea pigs were immunized as described in Table 1.
- bAnimals were killed 30 days after infection and the lung cellular infiltrates were measured and expressed as percent of cellular infiltrate in lung parenchyma.
- * Indicate that the effects of vaccination were highly significant compared with data from animals not vaccinated and challenged with M. tuberculosis (Student's t-tests, P < 0.001).