Figure 1From: Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 genesiNS1 prevents RSV-induced lung pathology and reduces virus titer in the lung. Rats were given intranasal treatments with chitosan-vector nanocomplexes of siNS1 or unrelated siRNA (control) followed 24 h later by intranasal inoculation with RSV. Five days later, the rats (n = 4) were sacrificed and lungs were removed, sectioned and stained for microscopic examination. The experiment was repeated once and a representative photomicrograph is shown (A). Another group of rats (n = 6) treated in the same way was used to determine RSV levels in the lung. Homogenates of lung tissue were assayed for RSV titer by immunofluorescence (B, *p < 0.05).Back to article page