Skip to main content
Figure 2 | Genetic Vaccines and Therapy

Figure 2

From: Chitosan IFN-γ-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma

Figure 2

Prevention of AHR. (A) Prophylaxis protocol. (B) Mice were challenged with methacholine on day 22 to measure airway responsiveness. The values are mean enhanced pause (PENH) expressed as percent of baseline ± SEM (* P < 0.05 and **P < 0.01). (C) On day 24, BAL was performed and differential cell counts were obtained ('mac', macrophages; 'lym', lymphocytes; 'neu', neutrophils; 'eos', eosinophils). (D) On day 24, lungs were removed, sectioned and the sections stained with hematoxylin/eosin ('PBS', phosphate-buffered saline control; 'N-DNA', naked DNA without chitosan; 'CIN', chitosan-DNA complex). Differential cell counts and examination of tissue sections were performed by different persons in a blinded fashion. Representative results are shown.

Back to article page