Table 2 Open field and elevated plus maze tests performed before applying gene therapy
Open Field | Elevated plus maze | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Freezing (s) | Grooming (s) | Rearing (#) | IS (#) | ES (#) | TS (#) | OA (#) | OA (s) | CA (#) | CA (s) | ||
12 week-old mice | |||||||||||
WT (n = 5) | mean | 9.4 | 10.4 | 46.4 | 79 | 136.6 | 215.6 | 2.8 | 29 | 9.2 | 223.2 |
SD | 5 | 6.7 | 10.8 | 22 | 25.3 | 44.8 | 1.5 | 24.9 | 3.3 | 23.4 | |
KO (n = 10) | mean | 15.1 | 12.1 | 32.2 | 42.5 | 114.7 | 157.2 | 2.8 | 42.9 | 6.4 | 194.5 |
SD | 9.6 | 6.7 | 14.1 | 14.3 | 38.5 | 42.6 | 2.8 | 47.4 | 4.3 | 60.2 | |
p <0.05 | p < 0.05 | ||||||||||
25 week-old mice | |||||||||||
WT (n = 3) | mean | 25.3 | 10 | 37.3 | 49 | 74 | 123 | 2.3 | 55.3 | 8.3 | 182 |
SD | 15.9 | 4 | 24.1 | 34.7 | 15.9 | 50.4 | 0.6 | 64.7 | 5.7 | 113.6 | |
KO (n = 5) | mean | 24.4 | 9.1 | 23.7 | 33.9 | 70.9 | 104.7 | 2.6 | 25.9 | 4.5 | 193 |
SD | 10 | 6 | 13 | 13.6 | 38 | 46.4 | 3.1 | 25.9 | 3.0 | 49.4 | |