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Table 2 Open field and elevated plus maze tests performed before applying gene therapy

From: Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

   Open Field Elevated plus maze
  Freezing (s) Grooming (s) Rearing (#) IS (#) ES (#) TS (#) OA (#) OA (s) CA (#) CA (s)
12 week-old mice  
WT (n = 5) mean 9.4 10.4 46.4 79 136.6 215.6 2.8 29 9.2 223.2
  SD 5 6.7 10.8 22 25.3 44.8 1.5 24.9 3.3 23.4
KO (n = 10) mean 15.1 12.1 32.2 42.5 114.7 157.2 2.8 42.9 6.4 194.5
  SD 9.6 6.7 14.1 14.3 38.5 42.6 2.8 47.4 4.3 60.2
      p <0.05   p < 0.05     
25 week-old mice  
WT (n = 3) mean 25.3 10 37.3 49 74 123 2.3 55.3 8.3 182
  SD 15.9 4 24.1 34.7 15.9 50.4 0.6 64.7 5.7 113.6
KO (n = 5) mean 24.4 9.1 23.7 33.9 70.9 104.7 2.6 25.9 4.5 193
  SD 10 6 13 13.6 38 46.4 3.1 25.9 3.0 49.4