Table 3 Open field and elevated plus maze tests performed after applying gene therapy
Open Field | Elevated plus maze | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Freezing (s) | Grooming (s) | Rearing (#) | IS (#) | ES (#) | TS (#) | OA (#) | OA (s) | CA (#) | CA (s) | ||
20 week-old mice | |||||||||||
WT (n = 4) | mean | 8.8 | 8 | 12.3 | 28.5 | 86.5 | 115 | 1.5 | 38.3 | 4.3 | 170.3 |
SD | 7.8 | 7.3 | 5.8 | 8.7 | 23.5 | 28.6 | 1.9 | 72.6 | 2.1 | 135.7 | |
KO (n = 3) | mean | 5,0 | 6,7 | 14,3 | 10,7 | 39,0 | 49,7 | 0,7 | 3,3 | 3,0 | 231,7 |
SD | 4,0 | 7,2 | 11,6 | 10,0 | 7,5 | 16,1 | 0,6 | 3,1 | 1,0 | 40,8 | |
KO/IDUA (5) | mean | 8.6 | 9.2 | 16.2 | 29.4 | 77.8 | 107.2 | 1 | 11.2 | 5.2 | 270.8 |
SD | 9.6 | 2.8 | 6.5 | 4 | 29 | 31.8 | 0.7 | 8.8 | 4.5 | 19.9 | |
29 week-old mice | |||||||||||
WT (n = 3) | mean | 8.7 | 9.3 | 6.7 | 17 | 45.3 | 62.3 | 0.3 | 1.7 | 2.7 | 286 |
SD | 5.5 | 8.1 | 3.8 | 5.3 | 27.6 | 32.9 | 0.6 | 2.9 | 1.5 | 3.5 | |
KO (n = 4) | mean | 5.0 | 5.2 | 1.7 | 8.7 | 23.5 | 32.2 | 1.2 | 93.5 | 1.5 | 93.5 |
SD | 2.9 | 4.1 | 2.4 | 7.6 | 11.4 | 18.0 | 1.3 | 130.2 | 1.3 | 124.5 | |
KO/IDUA (3) | mean | 5.7 | 5.7 | 11 | 16 | 56 | 72 | 0.7 | 4 | 3.3 | 283 |
SD | 2.1 | 2.1 | 14.2 | 13.1 | 45.2 | 58.3 | 1.2 | 6.9 | 2.1 | 14.2 | |