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Table 3 Open field and elevated plus maze tests performed after applying gene therapy

From: Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

   Open Field Elevated plus maze
  Freezing (s) Grooming (s) Rearing (#) IS (#) ES (#) TS (#) OA (#) OA (s) CA (#) CA (s)
20 week-old mice  
WT (n = 4) mean 8.8 8 12.3 28.5 86.5 115 1.5 38.3 4.3 170.3
  SD 7.8 7.3 5.8 8.7 23.5 28.6 1.9 72.6 2.1 135.7
KO (n = 3) mean 5,0 6,7 14,3 10,7 39,0 49,7 0,7 3,3 3,0 231,7
  SD 4,0 7,2 11,6 10,0 7,5 16,1 0,6 3,1 1,0 40,8
KO/IDUA (5) mean 8.6 9.2 16.2 29.4 77.8 107.2 1 11.2 5.2 270.8
  SD 9.6 2.8 6.5 4 29 31.8 0.7 8.8 4.5 19.9
29 week-old mice  
WT (n = 3) mean 8.7 9.3 6.7 17 45.3 62.3 0.3 1.7 2.7 286
  SD 5.5 8.1 3.8 5.3 27.6 32.9 0.6 2.9 1.5 3.5
KO (n = 4) mean 5.0 5.2 1.7 8.7 23.5 32.2 1.2 93.5 1.5 93.5
  SD 2.9 4.1 2.4 7.6 11.4 18.0 1.3 130.2 1.3 124.5
KO/IDUA (3) mean 5.7 5.7 11 16 56 72 0.7 4 3.3 283
  SD 2.1 2.1 14.2 13.1 45.2 58.3 1.2 6.9 2.1 14.2