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Figure 1 | Genetic Vaccines and Therapy

Figure 1

From: Comparison of bovine leukemia virus (BLV) and CMV promoter-driven reporter gene expression in BLV-infected and non-infected cells

Figure 1

Schematic representation of BLV promoter used in comparison studies. The BLV promoter (BLVp) consisting of the U3 region of the 5'LTR of BLV includes the basic elements of transcription start site (+1), CAAT (nt -97/-92) and TATA (nt -43/-37) boxes as shown. Unique to the BLVp are the three imperfectly conserved 21 bp sequences known as the Tax Responsive Elements (TxRE). The numbers following the TxRE designation represent its position relative to the transcription start site. Each TxRE contains a consensus E box-binding motif overlapping an imperfect cyclic AMP responsive element motif (CRE/Ebox). Additionally, the BLVp contains a glucocorticoid responsive element (GRE), Nuclear Factor Kappa Binding motif (NFkB), and B cell specific PU.1 or Spi-B transactivator binding motif (PU.1/Spi-B). The transcription elements are not drawn to scale.

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Genetic Vaccines and Therapy

ISSN: 1479-0556