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Figure 1 | Genetic Vaccines and Therapy

Figure 1

From: Recombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescue

Figure 1

RPE65-positive immunohistochemical labelling in the retinas of Rpe65-/- mice after injection with rAAV.RPE65 Labeling in the retinal pigment epithelium is seen at 7 mo post-injection (A). The signal continues for some distance (more than 600 μm) away from the injection site. This labeling is not seen in the uninjected, age-matched control Rpe65-/- mouse (B). At 11 mo post-injection positive labeling is seen both close to (C), and more distant from (400 μm, D), the injection site (C) although the signal is more discrete. This pattern of labeling near to (E) and distant from (>300 μm, F) the injection site persists at 18 mo post-injection (E, F). Scale bar: A = 100 μm; B-F = 50 μm. Small arrows point to positively labeled cells, large arrows point to injection site.

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Genetic Vaccines and Therapy

ISSN: 1479-0556