Skip to main content


Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Figure 2 | Genetic Vaccines and Therapy

Figure 2

From: A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivoimaging of gene therapy in malignant glioma

Figure 2

Comparison of the enzymatic activities of the HSV-TK-Luc fusion protein, HSV-TK, and Luc. U87MG cells were transiently transfected with 0.05 – 2 μg of HSV-TK-Luc, Luc, or HSV-TK plasmid. Cells transfected with equimolar amounts of DNA were analyzed for cytotoxic and bioluminescent activity. (A) Cytotoxic activity of cells transfected with HSV-TK-Luc or HSV-TK. For reasons of clarity only the graphs for 0.1 μg and 2 μg of transfected DNA are shown. (B) Luciferase activity in U87MG cells transfected with HSV-TK-Luc or Luc only. Results represent 3 independent experiments.

Back to article page