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Figure 3 | Genetic Vaccines and Therapy

Figure 3

From: A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivoimaging of gene therapy in malignant glioma

Figure 3

Correlation of light emission with cytotoxicity in intact U87MG glioma cells stably expressing the HSV-TK-Luc fusion construct and treated with GCV. (A) Cytotoxic activity as determined by MTT assay. (B) Bioluminescence imaging of quadruplicates of intact U87MG cells treated with the indicated amounts of GCV or left untreated (control). (C) Linear regression analysis of photon emission detected by the CCD camera plotted against cytotoxicity (R2 = 0.94; p = 0.029).

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