Figure 6From: A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivoimaging of gene therapy in malignant gliomaLinear regression analysis. Light emission as determined by the CCD camera was plotted against tumor volume. Mean values for all animals in a group along with the S.E.M are reported. (A) GCV treated mice: mice (n = 7) were imaged at start of therapy, after 1 and 2 weeks of GCV treatment, and 1 and 5 weeks after end of GCV therapy (R2 = 0.93, p = 0.008). In some mice additional images were acquired (Figure 5), but these were not included in this plot. (B) Saline treated control mice: these mice (n = 3) were imaged on days 7, 22, 29, and 35 and were sacrificed after the last BLI due to massive tumor growth (R2 = 0.98, p = 0.010).Back to article page