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Figure 4 | Genetic Vaccines and Therapy

Figure 4

From: Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage

Figure 4

Comparative priming of neonate mice with pVAXhsp65 and BCG for specific anti-hsp65 antibody production. Five-day-old mice received a priming dose of pVAXhsp65 or BCG and then two pVAXhsp65 doses at the adult phase; experimental groups were identified as DNA/DNA and BCG/DNA respectively. A non-immunized group and a group immunized with 3 pVAXhsp65 doses delivered at 5, 12 and 19-day-old were identified as control and neonate, respectively. Two weeks after last dose, the serum levels of IgG1 (a) and IgG2a (b) anti-hsp65 antibodies were evaluated by ELISA. Results represent the geometric mean ± SEM of 6 – 8 individually tested animals per group. *p < 0.05 in comparison to neonate group.

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