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Figure 1 | Genetic Vaccines and Therapy

Figure 1

From: Rapid, widespread transduction of the murine myocardium using self-complementary Adeno-associated virus

Figure 1

Maps of scAAV and ssAAV. (A) A schematic representation of the single-stranded (ss) AAV genome containing a full-length actin intron as well as a Neomycin resistance cassette. This construct contains the CBA promoter driving the expression of GFP. (B) A schematic representation of the self-complementary (sc) AAV genome containing a mutated 5' inverted terminal repeat (ITR), an actin intron from which 722 nucleotides have been deleted, and no Neomycin resistance cassette. This construct also contains the CBA promoter driving the expression of GFP. Both of these constructs contain the AAV2 ITRs and were packaged into AAV1 capsids.

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