Genetic Vaccines and Therapy

Table 3 Percent of cellular infiltrate in lung parenchyma of animals vaccinated and challenged with M. tuberculosis

From: Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs

Formulations^a	Mice^b	Guine-pigs^b
No vaccination	74 ± 8	69 ± 9
BCG	18 ± 5*	24 ± 4*
DNAv (naked DNA)	72 ± 9	65 ± 7
DNAhsp65 (naked DNA)	38 ± 7*	42 ± 6*
Me-DNAhsp65/TDM	41 ± 6*	40 ± 7*
Me-Prime/boost	37 ± 5*	38 ± 6*

^aMice and guinea pigs were immunized as described in Table 1.
^bAnimals were killed 30 days after infection and the lung cellular infiltrates were measured and expressed as percent of cellular infiltrate in lung parenchyma.
* Indicate that the effects of vaccination were highly significant compared with data from animals not vaccinated and challenged with M. tuberculosis (Student's t-tests, P < 0.001).

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