|
Formulationsa
|
Miceb
|
Guine-pigsb
|
|---|
|
No vaccination
|
74 ± 8
|
69 ± 9
|
|
BCG
|
18 ± 5*
|
24 ± 4*
|
|
DNAv (naked DNA)
|
72 ± 9
|
65 ± 7
|
|
DNAhsp65 (naked DNA)
|
38 ± 7*
|
42 ± 6*
|
|
Me-DNAhsp65/TDM
|
41 ± 6*
|
40 ± 7*
|
|
Me-Prime/boost
|
37 ± 5*
|
38 ± 6*
|
- aMice and guinea pigs were immunized as described in Table 1.
- bAnimals were killed 30 days after infection and the lung cellular infiltrates were measured and expressed as percent of cellular infiltrate in lung parenchyma.
- * Indicate that the effects of vaccination were highly significant compared with data from animals not vaccinated and challenged with M. tuberculosis (Student's t-tests, P < 0.001).
