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Figure 1 | Genetic Vaccines and Therapy

Figure 1

From: Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene

Figure 1

siNS1 prevents RSV-induced lung pathology and reduces virus titer in the lung. Rats were given intranasal treatments with chitosan-vector nanocomplexes of siNS1 or unrelated siRNA (control) followed 24 h later by intranasal inoculation with RSV. Five days later, the rats (n = 4) were sacrificed and lungs were removed, sectioned and stained for microscopic examination. The experiment was repeated once and a representative photomicrograph is shown (A). Another group of rats (n = 6) treated in the same way was used to determine RSV levels in the lung. Homogenates of lung tissue were assayed for RSV titer by immunofluorescence (B, *p < 0.05).

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