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Figure 1 | Genetic Vaccines and Therapy

Figure 1

From: Is gene therapy a good therapeutic approach for HIV-positive patients?

Figure 1

Schematic representation of the life cycle of HIV and the various steps at which anti- HIV gene therapy could be applied with key viral target proteins in parentheses: (1) HIV-1 attachment and binding (Env, gp120); (2) HIV-1 entry (Env, gp41); (3) Reverse transcription (reverse transcriptase and Vif); (4) Transport of HIV-1 DNA into the nucleus and integration with cellular DNA (Vpr, matrix, integrase). (5) Transcription of the HIV-1 proviral genome to produce both spliced and unspliced HIV-1 RNAs (Tat); (6) Transport of HIV-1 transcripts to cytoplasm (Rev); (7) HIV-1 gene expression and posttranslational modification of HIV-1 proteins (Gag, Gag-Pol, and Env polyproteins, Vif, and Nef). (8) HIV-1 virion assembly and morphogenesis within the cell (all virion proteins). (9) Release and maturation of the immature virion into a completely infectious particle (protease, Vpu, and Nef).

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