Genetic Vaccines and Therapy

Table 1 Heterologous prime-boost regimen combinations

From: Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming

GROUP	PRIME	BOOSTER^a
PBS	PBS	PBS
BCGsc	Subcutaneous^b BCG	-
BCGin	Intranasal^c BCG	-
BCGin/DNA	Intranasal BCG	Intramuscular^d DNA-hsp65
BCGsc/DNA	Subcutaneous BCG	Intramuscular DNA-hsp65
DNA-hsp65	3 doses of intramuscular^d	DNA-hsp65 – 15 days of interval

^aInterval between prime and booster: 15 days
^bSubcutaneous route: 10⁵ bacteria in 30 microliters
^cIntranasal route: 10⁵ bacteria in 100 microliters
^dIntramuscular route: 100 micrograms in 100 microliters/dose, 3 doses at 15-day intervals

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