Table 1 Encapsulation efficiency and median diameter of different microsphere formulation
From: Tissue distribution of DNA-Hsp65/TDM-loaded PLGA microspheres and uptake by phagocytic cells
| Microspheres | Encapsulation efficiency | Values of diameter distribution (mean ± SD, μm) |
|---|---|---|
| pcDNA3-Hsp65/TDM (6.6 mg 6-coumarin) | 49.9% (6.25 μg DNA/mg of microspheres) | 3.6 ± 0.27 |
| pcDNA3/TDM (6.6 mg 6-coumarin) | 24% (3.0 μg DNA/mg of microspheres) | 3.6 ± 0.29 |
| pcDNA3-Hsp65/TDM (60 μg 6-coumarin) | 52.8% (6.6 μg DNA/mg of microspheres) | 3.9 ± 0.25 |
| pcDNA3-Hsp65/TDM (without 6-coumarin) | 34.4% (4.3 μg DNA/mg of microspheres) | 3.6 ± 0.22 |
| empty (6.6 mg 6-coumarin) | --- | 4.8 ± 0.32 |