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Table 2 Gene transfer efficiency of K562-targeted and standard rAAV2 vectors on solid tumour cells.

From: Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line

 

%GFP+ cells

MFI (AU)

Cell line

EARVRPP

rAAV2

EARVRPP

rAAV2

RM-HS-1

46.01 ± 10.82

97.61 ± 3.21

35.03 ± 12.93

395.64 ± 52.93

H-Meso1

76.42 ± 2.41

88.30 ± 4.34

70.29 ± 9.54

150.89 ± 23.22

HeLa-RC

77.94 ± 6.60

98.22 ± 1.21

32.57 ± 7.73

143.49 ± 12.21

  1. A significant (p < 0.05; irrespective of cell line) superiority of the standard rAAV2 vector on three solid tumour cell lines could be shown for both %GFP+ cells and MFI. MFI: mean fluorescence intensity; AU: Arbitrary units.