TY - JOUR AU - Pacak, Christina A. AU - Conlon, Thomas AU - Mah, Cathryn S. AU - Byrne, Barry J. PY - 2008 DA - 2008/10/15 TI - Relative persistence of AAV serotype 1 vector genomes in dystrophic muscle JO - Genetic Vaccines and Therapy SP - 14 VL - 6 IS - 1 AB - The purpose of this study was to assess the behavior of pseudotyped recombinant adeno-associated virus type 1 (rAAV2/1) vector genomes in dystrophic skeletal muscle. A comparison was made between a therapeutic vector and a reporter vector by injecting the hindlimb in a mouse model of Limb Girdle Muscular Dystrophy Type 2D (LGMD-2D) prior to disease onset. We hypothesized that the therapeutic vector would establish long-term persistence through prevention of myofiber turnover. In contrast, the reporter vector genome copy number would diminish over time due to disease-associated muscle degradation. SN - 1479-0556 UR - https://doi.org/10.1186/1479-0556-6-14 DO - 10.1186/1479-0556-6-14 ID - Pacak2008 ER -