Genetic Vaccines and Therapy

Table 1 Tissue damage after three deliveries on days 0, 2, and 4.

From: Comparison of electrically mediated and liposome-complexed plasmid DNA delivery to the skin

	DNA+EP-	DNA-EP+	DNA+EP+
Surface Damage
Day 4	1.3 ± 0.5	14.2 ± 4.4**	9.5 ± 3.5
Day 6	2.4 ± 1.9	11.0 ± 3.0**	10.7 ± 3.0*
Inflammation
Day 4	68.1 ± 12.7	100 ± 0	75.0 ± 11.5
Day 6	66.7 ± 11.2	95.8 ± 4.2	59.7 ± 10.3
Bullae
Day 4	4.2 ± 4.2	47.2 ± 11.2*	43.1 ± 13.7
Day 6	4.2 ± 4.2	37.5 ± 6.5*	52.7 ± 13.1**
Muscle Degeneration
Day 4	59.7 ± 12.0	97.9 ± 2.1*	72.2 ± 11.3
Day 6	66.7 ± 9.4	95.8 ± 4.2	52.8 ± 11.6
Subepidermal Necrosis
Day 4	8.3 ± 5.6	48.6 ± 10.7*	43.8 ± 13.8
Day 6	12.5 ± 9.0	50.0 ± 10.7*	40.3 ± 13.5

Values represent the mean and SEM for three independent experiments (n = 4) for a total of 12 samples.
DNA, gWizLuc
EP, electroporation
**p < 0.01
*p < 0.05

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