Table 2 Tissue damage after three deliveries on days 0, 10, and 20.
From: Comparison of electrically mediated and liposome-complexed plasmid DNA delivery to the skin
| Â | DNA+EP- | DNA-EP+ | DNA+EP+ |
|---|---|---|---|
Surface Damage | |||
Day 12 | 2.4 ± 0.9 | 0.5 ± 0.2 | 3.0 ± 1.2 |
Day 22 | 3.8 ± 1.1 | 0.3 ± 0.2* | 3.0 ± 1.1 |
Inflammation | |||
Day 12 | 68.0 ± 12.7 | 68.0 ± 9.3 | 95.8 ± 4.2 |
Day 22 | 52.6 ± 11.8 | 95.8 ± 4.2** | 77.8 ± 6.9 |
Bullae | |||
Day 12 | 31.9 ± 14.1 | 8.3 ± 5.6 | 29.2 ± 13.2 |
Day 22 | 12.7 ± 5.9 | 4.2 ± 4.2 | 23.6 ± 9.5 |
Muscle Degeneration | |||
Day 12 | 68.0 ± 12.7 | 48.6 ± 10.7 | 84.7 ± 9.0 |
Day 22 | 55.1 ± 11.2 | 66.7 ± 11.2 | 79.2 ± 7.7 |
Subepidermal Necrosis | |||
Day 12 | 23.6 ± 12.88 | 12.5 ± 8.5 | 38.9 ± 14.1 |
Day 22 | 25.9 ± 8.8 | 4.2 ± 4.2 | 16.7 ± 9.4 |