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Figure 3 | Genetic Vaccines and Therapy

Figure 3

From: Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector

Figure 3

Quantification of luciferase activities in various organs following i.n delivery of AdLuc. After intranasal delivery of AdLuc, mice were sacrificed at days 1, 3, 7 and 12. The trachea (A), lung (B), olfactory bulb (C), brain (D), cervical lymph nodes (E) and spleen (F) were harvested and processed for the luciferase assay. Results are expressed as mean ± SEM from three mice/time point for AdLuc treatment. One mouse/time point was set up for naïve control measurement. The significance of differences in luciferase activities in the lung is as follows: it is significantly different between days 3/7 and day 1 or day 12 (p ≤ 0.01), but the difference between day 3 and day 7 is not significant (p = 0.1). There is no statistically significant difference between all time points in Fig. 3C.

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Genetic Vaccines and Therapy

ISSN: 1479-0556