Skip to main content
Figure 3 | Genetic Vaccines and Therapy

Figure 3

From: Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats

Figure 3

Histological analysis of human FIX expression in livers of AAV8-LP1-hFIX infused rats. Representative liver sections of immunohistochemical staining for hFIX 4 months after gene transfer in rats infused with scAAV8-LP1-hFIX at (A) 5 × 1011vg/rat, (B) 1 × 1011vg/rat, (C) 5 × 1010vg/rat, (D) 1 × 1010vg/rat or (E) saline. Paraffin liver sections were stained for human FIX expression using goat anti-human FIX conjugated to horse-radish peroxidase and goat IgG was used as the negative control (F). Magnification is × 40.

Back to article page