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Figure 3 | Genetic Vaccines and Therapy

Figure 3

From: The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model

Figure 3

Therapeutic effects of Sec-N'-EGFR DNA vaccine administered by three different methods on established tumor in B6 mice. Five days after subcutaneous tumor implantation with 1 × 106 LL2 tumor cells., mice were administrated with DNA vaccine four times (day 5, 12, 19, 26) at weekly intervals; (A) tumor volume was measured at the indicated time. Data are means of the animals per group; bars, ± S.D. (B) lifespan of mice after subcutaneous challenge. The survival data were subjected to Kaplan-Meier analysis. The digit in the parenthesis is the number of mice in the experiment. The symbol (*) indicates a statistically significant difference when compared with the control saline mice (P < 0.01). The symbol (**) indicates a statistically significant difference when compared with the i.m and g.g gold-coated DNA group mice (P < 0.05) or control mice (P < 0.001). The experiments were repeated 2 times with similar results.

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Genetic Vaccines and Therapy

ISSN: 1479-0556