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Figure 8 | Genetic Vaccines and Therapy

Figure 8

From: The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model

Figure 8

The effects of CD8+ T cell-depletion or CD4+ T cell-depletion on the therapeutic effects of non-coating EGFR DNA vaccine by gene gun administration (A) Protocol for depletion of CD8+ or CD4+ T cells in vivo. Tumor-bearing mice were injected i.p with 500 μg of anti-CD8 antibody or 300 μg of anti-CD4 antibody at weekly intervals starting from 2 days before the first inoculation of DNA vaccine. (B) Life span of B6 mice after sc challenge with LL2 tumor cells. ** represents statistically significant difference when compared to the control saline group of mice (P < 0.01). The experiments were repeated twice with experimental groups.

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Genetic Vaccines and Therapy

ISSN: 1479-0556