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Figure 6 | Genetic Vaccines and Therapy

Figure 6

From: Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen

Figure 6

Core-specific immune response in BALB/c mice immunized with the recombinant N-terminal domain of HCV core aa 1–98 alone (n = 5); with pCMVcoreKozak (n = 7); and primed with pCMVcoreKozak and boosted with HCV core aa 1–98 (n = 6). The kinetics of IgG response to core aa 1–98 (A);-T-cell proliferation measured as the stimulation index (SI) in response to HCV core aa 1–98, recombinant core aa 1–173, and a peptide covering HCV core aa 133–142 (B); levels of core-specific IFN-γ and IL-2 secretion (pg/ml) in the pooled cell culture after splenocyte stimulation with HCV core aa 1–98 or aa 1–173 (C).

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