TY - JOUR AU - Jazwa, Agnieszka AU - Kucharzewska, Paulina AU - Leja, Justyna AU - Zagorska, Anna AU - Sierpniowska, Aleksandra AU - Stepniewski, Jacek AU - Kozakowska, Magdalena AU - Taha, Hevidar AU - Ochiya, Takahiro AU - Derlacz, Rafal AU - Vahakangas, Elisa AU - Yla-Herttuala, Seppo AU - Jozkowicz, Alicja AU - Dulak, Jozef PY - 2010 DA - 2010/08/30 TI - Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice JO - Genetic Vaccines and Therapy SP - 6 VL - 8 IS - 1 AB - Impaired wound healing in diabetes is related to decreased production of growth factors. Hence, gene therapy is considered as promising treatment modality. So far, efforts concentrated on single gene therapy with particular emphasis on vascular endothelial growth factor-A (VEGF-A). However, as multiple proteins are involved in this process it is rational to test new approaches. Therefore, the aim of this study was to investigate whether single AAV vector-mediated simultaneous transfer of VEGF-A and fibroblast growth factor 4 (FGF4) coding sequences will improve the wound healing over the effect of VEGF-A in diabetic (db/db) mice. SN - 1479-0556 UR - https://doi.org/10.1186/1479-0556-8-6 DO - 10.1186/1479-0556-8-6 ID - Jazwa2010 ER -