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Figure 6 | Genetic Vaccines and Therapy

Figure 6

From: Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice

Figure 6

AAV-VEGF-A stimulates skin neovascularization in db/db mice 21 days after wounding and gene transfer. (A) Representative pictures demonstrating isolectin B4 binding and expression of proliferating cell nuclear antigen (PCNA) (arrows). DAPI was used to confirm the nuclear localization of PCNA (arrow). (B) The number of proliferating capillary endothelial cells was increased after AAV-VEGF-A injection. (C) Total number of capillaries was also increased only after AAV-VEGF-A administration. Graphs represent means ± SEM (n = 5 animals/group); *p < 0.05 vs PBS and AAV-LacZ; # p < 0.05 vs PBS. Scale bar = 0.01 mm.

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