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Figure 8 | Genetic Vaccines and Therapy

Figure 8

From: Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice

Figure 8

rhFGF4 stimulates MMP-9 and Flt-1 expression in diabetic mouse dermal fibroblasts. (A) There are no significant differences in the basal MMP-9 expression between WT and db/db fibroblasts cultured either in low (5.5 mM) or high (25 mM) glucose. (B) MMP-9 expression is up-regulated upon single rhFGF4 or combined with rhVEGF-A treatment in db/db fibroblasts cultured in hyperglycemic conditions. (C) There are no significant differences in the basal Flt-1 expression between WT and db/db fibroblasts cultured either in low (5.5 mM) or high (25 mM) glucose. (D) Flt-1 expression is up-regulated upon single rhFGF4 or combined with rhVEGF-A treatment in db/db fibroblasts cultured in hyperglycemic conditions. C - control, V - rhVEGF-A (50 ng ml-1), F - rhFGF4 (50 ng ml-1), V+F - rhVEGF-A (50 ng ml-1) and rhFGF4 (50 ng ml-1). Graphs represent means ± SEM from n = 3 independent experiments performed in duplicates; *p < 0.05 vs control.

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