TY - JOUR AU - Alyamkina, Ekaterina A. AU - Nikolin, Valeriy P. AU - Popova, Nelly A. AU - Dolgova, Evgenia V. AU - Proskurina, Anastasia S. AU - Orishchenko, Konstantin E. AU - Efremov, Yaroslav R. AU - Chernykh, Elena R. AU - Ostanin, Alexandr A. AU - Sidorov, Sergey V. AU - Ponomarenko, Dmitriy M. AU - Zagrebelniy, Stanislav N. AU - Bogachev, Sergey S. AU - Shurdov, Mikhail A. PY - 2010 DA - 2010/11/01 TI - A strategy of tumor treatment in mice with doxorubicin-cyclophosphamide combination based on dendritic cell activation by human double-stranded DNA preparation JO - Genetic Vaccines and Therapy SP - 7 VL - 8 IS - 1 AB - Immunization of mice with tumor homogenate after combined treatment with cyclophosphamide (CP) and double-stranded DNA (dsDNA) preparation is effective at inhibition of growth of tumor challenged after the treatment. It was assumed that this inhibition might be due to activation of the antigen-presenting cells. The purpose was to develop improved antitumor strategy using mice. We studied the combined action of cytostatics doxorubicin (Dox) plus CP with subsequent dsDNA preparation on tumor growth. SN - 1479-0556 UR - https://doi.org/10.1186/1479-0556-8-7 DO - 10.1186/1479-0556-8-7 ID - Alyamkina2010 ER -