TY - JOUR AU - Jahan, Shah AU - Samreen, Baila AU - Khaliq, Saba AU - Ijaz, Bushra AU - Khan, Mahwish AU - Siddique, Muhammad Hassan AU - Ahmad, Waqar AU - Hassan, Sajida PY - 2011 DA - 2011/09/06 TI - HCV entry receptors as potential targets for siRNA-based inhibition of HCV JO - Genetic Vaccines and Therapy SP - 15 VL - 9 IS - 1 AB - Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The current therapy of interferon-α and ribavirin against HCV has limited efficiency, so alternative options are desperately needed. RNA interference (RNAi), which results in a sequence-specific degradation of HCV RNA has potential as a powerful alternative molecular therapeutic approach. Concerning viral entry, the HCV structural gene E2 is mainly involved in virus attachment to the host cell surface receptors i.e., CD81 tetraspanin, scavenger receptor class B type 1 (SR-B1), low density lipoprotein receptor (LDLR) and claudin1 (CLDN1). SN - 1479-0556 UR - https://doi.org/10.1186/1479-0556-9-15 DO - 10.1186/1479-0556-9-15 ID - Jahan2011 ER -