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  1. Research

    AAV2-mediated in vivo immune gene therapy of solid tumours

    Many strategies have been adopted to unleash the potential of gene therapy for cancer, involving a wide range of therapeutic genes delivered by various methods. Immune therapy has become one of the major strat...

    Sara A Collins, Alexandra Buhles, Martina F Scallan, Patrick T Harrison, Deirdre M O'Hanlon, Gerald C O'Sullivan and Mark Tangney

    Genetic Vaccines and Therapy 2010 8:8

    Published on: 20 December 2010

  2. Research

    A strategy of tumor treatment in mice with doxorubicin-cyclophosphamide combination based on dendritic cell activation by human double-stranded DNA preparation

    Immunization of mice with tumor homogenate after combined treatment with cyclophosphamide (CP) and double-stranded DNA (dsDNA) preparation is effective at inhibition of growth of tumor challenged after the tre...

    Ekaterina A Alyamkina, Valeriy P Nikolin, Nelly A Popova, Evgenia V Dolgova, Anastasia S Proskurina, Konstantin E Orishchenko, Yaroslav R Efremov, Elena R Chernykh, Alexandr A Ostanin, Sergey V Sidorov, Dmitriy M Ponomarenko, Stanislav N Zagrebelniy, Sergey S Bogachev and Mikhail A Shurdov

    Genetic Vaccines and Therapy 2010 8:7

    Published on: 1 November 2010

  3. Research

    Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice

    Impaired wound healing in diabetes is related to decreased production of growth factors. Hence, gene therapy is considered as promising treatment modality. So far, efforts concentrated on single gene therapy w...

    Agnieszka Jazwa, Paulina Kucharzewska, Justyna Leja, Anna Zagorska, Aleksandra Sierpniowska, Jacek Stepniewski, Magdalena Kozakowska, Hevidar Taha, Takahiro Ochiya, Rafal Derlacz, Elisa Vahakangas, Seppo Yla-Herttuala, Alicja Jozkowicz and Jozef Dulak

    Genetic Vaccines and Therapy 2010 8:6

    Published on: 30 August 2010

  4. Research

    Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensischallenge

    We have previously demonstrated protective efficacy against B. melitensis using formulations of naked DNA vaccines encoding genes ialB and omp25. The present study was undertaken to further understand the immune ...

    Nicola J Commander, James M Brewer, Brendan W Wren, Stephen A Spencer, Alastair P MacMillan and Judith A Stack

    Genetic Vaccines and Therapy 2010 8:5

    Published on: 16 July 2010

  5. Research

    Development of avian influenza virus H5 DNA vaccine and MDP-1 gene of Mycobacterium bovisas genetic adjuvant

    Studies have shown that DNA vaccines can induce protective immunity, which demonstrated the high potential of DNA vaccines as an alternative to inactivated vaccines. Vaccines are frequently formulated with adj...

    Babak Jalilian, Abdul Rahman Omar, Mohd Hair Bejo, Noorjahan Banu Alitheen, Mehdi Rasoli and Sohkichi Matsumoto

    Genetic Vaccines and Therapy 2010 8:4

    Published on: 24 May 2010

  6. Research

    Recombinant λ-phage nanobioparticles for tumor therapy in mice models

    Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little...

    Amir Ghaemi, Hoorieh Soleimanjahi, Pooria Gill, Zuhair Hassan, Soodeh Razeghi M Jahromi and Farzin Roohvand

    Genetic Vaccines and Therapy 2010 8:3

    Published on: 12 May 2010

  7. Research

    Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice

    Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens.

    Yaoli Wang, Chunxue Bai, Guansong Wang, Diane Wang, Xiaoming Cheng, Jian Huang, Dongpo Jiang, Guisheng Qian and Xiangdong Wang

    Genetic Vaccines and Therapy 2010 8:2

    Published on: 24 March 2010

  8. Research

    Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression

    Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoter...

    Alice T Trinh, Bret G Ball, Erin Weber, Timothy K Gallaher, Zoya Gluzman-Poltorak, French Anderson and Lena A Basile

    Genetic Vaccines and Therapy 2009 7:13

    Published on: 30 December 2009

  9. Research

    Combined therapy with cyclophosphamide and DNA preparation inhibits the tumor growth in mice

    When cyclophosphamide and preparations of fragmented exogenous genomic double stranded DNA were administered in sequence, the regressive effect on the tumor was synergic: this combined treatment had a more pro...

    Ekaterina A Alyamkina, Evgenia V Dolgova, Anastasia S Likhacheva, Vladimir A Rogachev, Tamara E Sebeleva, Valeriy P Nikolin, Nelly A Popova, Konstantin E Orishchenko, Dmitriy N Strunkin, Elena R Chernykh, Stanislav N Zagrebelniy, Sergei S Bogachev and Mikhail A Shurdov

    Genetic Vaccines and Therapy 2009 7:12

    Published on: 14 August 2009

  10. Research

    Dietary restriction abrogates antibody production induced by a DNA vaccine encoding the mycobacterial 65 kDa heat shock protein

    Protein-calorie malnutrition (PCM) is the most common type of malnutrition. PCM leads to immunodeficiency and consequent increased susceptibility to infectious agents. In addition, responses to prophylactic va...

    Larissa Lumi Watanabe Ishikawa, Thaís Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Nelson Mendes Marra, Paulo Câmara Marques Pereira, Célio Lopes Silva and Alexandrina Sartori

    Genetic Vaccines and Therapy 2009 7:11

    Published on: 16 July 2009

  11. Research

    Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models

    Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (Flk-1/KDR), play a key role in tumor angiogenesis. Blocking the VEGF-VEGFR-2 pathway may inhibit tumor growth. Here, we used human VEGFR-2 a...

    Ke Xie, Rui-Zhen Bai, Yang Wu, Quan Liu, Kang Liu and Yu-Quan Wei

    Genetic Vaccines and Therapy 2009 7:10

    Published on: 21 June 2009

  12. Research

    Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5

    The use of shRNAs to downregulate the expression of specific genes is now relatively routine in experimentation but still hypothetical for clinical application. A potential therapeutic approach for HIV-1 disea...

    Saki Shimizu, Masakazu Kamata, Panyamol Kittipongdaja, Kevin N Chen, Sanggu Kim, Shen Pang, Joshua Boyer, F Xiao-Feng Qin, Dong Sung An and Irvin SY Chen

    Genetic Vaccines and Therapy 2009 7:8

    Published on: 10 June 2009

  13. Research

    Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen

    Hepatitis C core protein is an attractive target for HCV vaccine aimed to exterminate HCV infected cells. However, although highly immunogenic in natural infection, core appears to have low immunogenicity in e...

    Ekaterina Alekseeva, Irina Sominskaya, Dace Skrastina, Irina Egorova, Elizaveta Starodubova, Eriks Kushners, Marija Mihailova, Natalia Petrakova, Ruta Bruvere, Tatyana Kozlovskaya, Maria Isaguliants and Paul Pumpens

    Genetic Vaccines and Therapy 2009 7:7

    Published on: 8 June 2009

  14. Short paper

    Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours

    The most common cause of death of cancer sufferers is through the occurrence of metastases. The metastatic behaviour of tumour cells is regulated by extracellular growth factors such as hepatocyte growth facto...

    Alexandra Buhles, Sara A Collins, Jan P van Pijkeren, Simon Rajendran, Michelle Miles, Gerald C O'Sullivan, Deirdre M O'Hanlon and Mark Tangney

    Genetic Vaccines and Therapy 2009 7:5

    Published on: 9 March 2009

  15. Research

    A new plasmid vector for DNA delivery using lactococci

    The use of food-grade lactococci as bacterial carriers to DNA delivery into epithelial cells is a new strategy to develop live oral DNA vaccine. Our goal was to develop a new plasmid, named pValac, for antigen...

    Valeria Guimarães, Sylvia Innocentin, Jean-Marc Chatel, François Lefèvre, Philippe Langella, Vasco Azevedo and Anderson Miyoshi

    Genetic Vaccines and Therapy 2009 7:4

    Published on: 10 February 2009

  16. Research

    The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model

    Tyrosine kinase inhibitor gefitinib is effective against lung cancer cells carrying mutant epidermal growth factor receptor (EGFR); however, it is not effective against lung cancer carrying normal EGFR. The br...

    Ming-Derg Lai, Meng-Chi Yen, Chiu-Mei Lin, Cheng-Fen Tu, Chun-Chin Wang, Pei-Shan Lin, Huei-Jiun Yang and Chi-Chen Lin

    Genetic Vaccines and Therapy 2009 7:2

    Published on: 30 January 2009

  17. Research

    Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer

    The delivery of therapeutic genes to the central nervous system (CNS) using viral vectors represents an appealing strategy for the treatment of nerve injury and disorders of the CNS. Important factors determin...

    Thais Federici, Robert Kutner, Xian-Yang Zhang, Hitoshi Kuroda, Noël Tordo, Nicholas M Boulis and Jakob Reiser

    Genetic Vaccines and Therapy 2009 7:1

    Published on: 13 January 2009

  18. Research

    Genetic immunization with Hantavirus vaccine combining expression of G2 glycoprotein and fused interleukin-2

    In this research, we developed a novel chimeric HTNV-IL-2-G2 DNA vaccine plasmid by genetically linking IL-2 gene to the G2 segment DNA and tested whether it could be a candidate vaccine. Chimeric gene was fir...

    Huang Hao, Li Xiu, Zhang Zehua, Jia Min, Hu Hongbo, Wu Zhihong, Zhu Zhenhua, Wan Xiaohong and Huang Hanju

    Genetic Vaccines and Therapy 2008 6:15

    Published on: 22 October 2008

  19. Short paper

    Relative persistence of AAV serotype 1 vector genomes in dystrophic muscle

    The purpose of this study was to assess the behavior of pseudotyped recombinant adeno-associated virus type 1 (rAAV2/1) vector genomes in dystrophic skeletal muscle. A comparison was made between a therapeutic...

    Christina A Pacak, Thomas Conlon, Cathryn S Mah and Barry J Byrne

    Genetic Vaccines and Therapy 2008 6:14

    Published on: 15 October 2008

  20. Short paper

    Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice

    The AAV9 capsid displays a high natural affinity for the heart following a single intravenous (IV) administration in both newborn and adult mice. It also results in substantial albeit relatively lower expressi...

    Christina A Pacak, Yoshihisa Sakai, Bijoy D Thattaliyath, Cathryn S Mah and Barry J Byrne

    Genetic Vaccines and Therapy 2008 6:13

    Published on: 23 September 2008

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