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Table 4 GAG concentration in brains of mice treated with gene therapy

From: Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

#

Groups

Total GAG

Mean ± SD

DS-HS (%)a

11

WT 20w

1140.4

1566 ± 419

6.2

12

WT 20w

1281.2

 

9.9

13

WT 20w

1997.3

 

32.1

14

WT 20w

1849.6

 

29.0

1

WT 29w

NE

1907 ± 212

23.8

2

WT 29w

2057.0

 

NE

3

WT 29w

1757.3

 

9.8

15

KO 20w

2741.0

2443 ± 470

40.0

16

KO 20w

2889.3

 

48.8

24

KO 20w

1850.0

 

50.0

25

KO 20w

2290.0

 

48.2

4

KO 29w

4345.0

3234 ± 1287

49.8

5

KO 29w

3235.5

 

47.7

26

KO 29w

1429.0

 

43.5

27

KO 29w

3930.0

 

57.3

19

KO/IDUA 20w

1220.2

2065 ± 487

37.3

20

KO/IDUA 20w

2323.0

 

42.1

21

KO/IDUA 20w

2404.4

 

46.1

22

KO/IDUA 20w

2296.0

 

49.2

23

KO/IDUA 20w

2083.0

 

49.4

8

KO/IDUA 29w

1656.0

1509 ± 364

42.6

9

KO/IDUA 29w

1778.9

 

39.8

10

KO/IDUA 29w

1094.2

 

55.6

  1. Total GAG is expressed in μg/g dry tissue; (#) Animal identification number;
  2. a % = [DS-HS]/[Total GAG] * 100; NE = non-evaluated; w = week-old.