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Table 4 GAG concentration in brains of mice treated with gene therapy

From: Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

# Groups Total GAG Mean ± SD DS-HS (%)a
11 WT 20w 1140.4 1566 ± 419 6.2
12 WT 20w 1281.2   9.9
13 WT 20w 1997.3   32.1
14 WT 20w 1849.6   29.0
1 WT 29w NE 1907 ± 212 23.8
2 WT 29w 2057.0   NE
3 WT 29w 1757.3   9.8
15 KO 20w 2741.0 2443 ± 470 40.0
16 KO 20w 2889.3   48.8
24 KO 20w 1850.0   50.0
25 KO 20w 2290.0   48.2
4 KO 29w 4345.0 3234 ± 1287 49.8
5 KO 29w 3235.5   47.7
26 KO 29w 1429.0   43.5
27 KO 29w 3930.0   57.3
19 KO/IDUA 20w 1220.2 2065 ± 487 37.3
20 KO/IDUA 20w 2323.0   42.1
21 KO/IDUA 20w 2404.4   46.1
22 KO/IDUA 20w 2296.0   49.2
23 KO/IDUA 20w 2083.0   49.4
8 KO/IDUA 29w 1656.0 1509 ± 364 42.6
9 KO/IDUA 29w 1778.9   39.8
10 KO/IDUA 29w 1094.2   55.6
  1. Total GAG is expressed in μg/g dry tissue; (#) Animal identification number;
  2. a % = [DS-HS]/[Total GAG] * 100; NE = non-evaluated; w = week-old.