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Genetic Vaccines and Therapy

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  1. Content type: Review

    Development of various vaccines for prostate cancer (PCa) is becoming an active research area. PCa vaccines are perceived to have less toxicity compared with the available cytotoxic agents. While various immun...

    Authors: Sarfraz Ahmad, Paul Sweeney, Gerald C Sullivan and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2012 10:9

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  2. Content type: Research

    Liver fluke can infect cattle and sheep, and is also emerging as a human pathogen in developing countries. Cathepsin B (Cat B2) is a major cysteine protease secreted by the juvenile flukes. To enhance the immu...

    Authors: Rama Jayaraj, David Piedrafita, Terry Spithill and Peter Smooker

    Citation: Genetic Vaccines and Therapy 2012 10:7

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  3. Content type: Research

    Malaria causes immense human morbidity and mortality globally. The plasmodium species vivax and falciparum cause over 75 % clinical malaria cases. Until now, gene-based strategies against malaria have only been a...

    Authors: Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera

    Citation: Genetic Vaccines and Therapy 2012 10:8

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  4. Content type: Research

    The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacio...

    Authors: David Hallengärd, Andreas Bråve, Maria Isaguliants, Pontus Blomberg, Jenny Enger, Richard Stout, Alan King and Britta Wahren

    Citation: Genetic Vaccines and Therapy 2012 10:5

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  5. Content type: Research

    Gp41 is an envelope glycoprotein of human immune deficiency virus (HIV). HIV viral glycoprotein gp41, present in complex with gp120, assists the viral entry into host cell. Over eighty thousands individuals ar...

    Authors: Syyada Samra Jafri, Saliha Kiran, Syed Babar Jamal and Masaud Shah

    Citation: Genetic Vaccines and Therapy 2012 10:4

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    The Retraction Note to this article has been published in Genetic Vaccines and Therapy 2012 10:10

  6. Content type: Research

    The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown...

    Authors: Ni-Chung Lee, Darin J Falk, Barry J Byrne, Thomas J Conlon, Nathalie Clement, Stacy Porvasnik, Marda L Jorgensen, Mark Potter, Kirsten E Erger, Rachael Watson, Steven C Ghivizzani, Hung-Chuan Chiu, Yin-Hsiu Chien and Wuh-Liang Hwu

    Citation: Genetic Vaccines and Therapy 2012 10:3

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  7. Content type: Research

    Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate. While the curre...

    Authors: Flávia Helena da Silva, Vanessa Gonçalves Pereira, Eduardo G Yasumura, Lígia Zacchi Tenório, Leonardo Pinto de Carvalho, Bianca Cristina Garcia Lisboa, Priscila Keiko Matsumoto, Roberta Sessa Stilhano, Vivian Y Samoto, Bruno Frederico Aguilar Calegare, Letícia de Campos Brandão, Vânia D’Almeida, Thaís RM Filippo, Marimélia Porcionatto, Leny Toma, Helena Bonciani Nader…

    Citation: Genetic Vaccines and Therapy 2012 10:2

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  8. Content type: Research

    Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The curre...

    Authors: Shah Jahan, Baila Samreen, Saba Khaliq, Bushra Ijaz, Mahwish Khan, Muhammad Hassan Siddique, Waqar Ahmad and Sajida Hassan

    Citation: Genetic Vaccines and Therapy 2011 9:15

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  9. Content type: Research

    A recently discovered occult HCV entity reported by various investigators seems to be highly controversial. Especially, the clinical significance of these findings remains uncertain. For optimal outcome of ant...

    Authors: Ambreen G Muazzam, Saleem Qureshi, Atika Mansoor, Lubna Ali, Musarrat Iqbal, Saima Siddiqi, Khalid M Khan and Kehkashan Mazhar

    Citation: Genetic Vaccines and Therapy 2011 9:14

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  10. Content type: Research

    Peptide/DNA complexes have great potential as non-viral methods for gene delivery. Despite promising results for peptide-mediated gene delivery technology, an effective systemic peptide-based gene delivery sys...

    Authors: Jung Gyu Woo, Na Young Kim, Jai Myung Yang and Sungho Shin

    Citation: Genetic Vaccines and Therapy 2011 9:13

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  11. Content type: Research

    Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis which progresses to hepatocellular carcinoma (HCC) afflicting > 170 million people worldwide. HCV 3a is the most common genotype (abo...

    Authors: Sadia Butt, Muhammad Idrees, Irshad-ur Rehman, Liaqat Ali, Abrar Hussain, Muhammad Ali, Naveed Ahmed, Sana Saleem and Madiha Fayyaz

    Citation: Genetic Vaccines and Therapy 2011 9:12

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  12. Content type: Review

    Hepatitis C virus (HCV) infection is a major worldwide problem causes acute and chronic HCV infection. Current treatment of HCV includes pegylated interferon-α (PEG IFN- α) plus ribavirin (RBV) which has signi...

    Authors: Sidra Rehman, Usman A Ashfaq and Tariq Javed

    Citation: Genetic Vaccines and Therapy 2011 9:11

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  13. Content type: Short report

    RNAi gene therapies for HIV-1 will likely need to employ multiple shRNAs to counter resistant strains. We evaluated 3 shRNA co-expression methods to determine their suitability for present use; multiple expres...

    Authors: Glen J Mcintyre, Allison J Arndt, Kirsten M Gillespie, Wendy M Mak and Gregory C Fanning

    Citation: Genetic Vaccines and Therapy 2011 9:9

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  14. Content type: Research

    The envelope glycoprotein of lymphocytic choriomeningitis virus (LCMV) can efficiently pseudotype lentiviral vectors. Some strains of LCMV exploit high affinity interactions with α-dystroglycan (α-DG) to bind ...

    Authors: Douglas E Dylla, Litao Xie, Daniel E Michele, Stefan Kunz and Paul B McCray Jr

    Citation: Genetic Vaccines and Therapy 2011 9:8

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  15. Content type: Review

    Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to h...

    Authors: Usman Ali Ashfaq, Shaheen N Khan, Zafar Nawaz and Sheikh Riazuddin

    Citation: Genetic Vaccines and Therapy 2011 9:7

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  16. Content type: Research

    Although B cells are important as antigen presenting cells (APC) during the immune response, their role in DNA vaccination models is unknown.

    Authors: Luciana P Almeida, Ana PF Trombone, Julio CC Lorenzi, Carolina D Rocha, Thiago Malardo, Isabela C Fontoura, Ana F Gembre, Ricardo LL Silva, Célio L Silva, Ademilson P Castelo and Arlete AM Coelho-Castelo

    Citation: Genetic Vaccines and Therapy 2011 9:5

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  17. Content type: Research

    Both adenoviral and lentiviral vectors have been successfully used to induce bone repair by over-expression of human bone morphogenetic protein 2 (BMP-2) in primary rat bone marrow stromal cells in pre-clinica...

    Authors: Farhang Alaee, Osamu Sugiyama, Mandeep S Virk, Ying Tang, Bing Wang and Jay R Lieberman

    Citation: Genetic Vaccines and Therapy 2011 9:4

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  18. Content type: Research

    Atrial natriuretic peptide (ANP) is an important endogenous hormone that controls inflammation and immunity by acting on dendritic cells (DCs); however, the mechanism remains unclear.

    Authors: Weidong Zhang, Xueqin Cao, Dongqing Chen, Jia-wang Wang, Hong Yang, Wenshi Wang, Subhra Mohapatra, Gary Hellermann, Xiaoyuan Kong, Richard F Lockey and Shyam S Mohapatra

    Citation: Genetic Vaccines and Therapy 2011 9:3

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  19. Content type: Research

    The efficacy and biosafety of lentiviral gene transfer is influenced by the design of the vector. To this end, properties of lentiviral vectors can be modified by using cis-acting elements such as the modificatio...

    Authors: Nicolas Grandchamp, Dorothée Henriot, Stéphanie Philippe, Lahouari Amar, Suzanna Ursulet, Che Serguera, Jacques Mallet and Chamsy Sarkis

    Citation: Genetic Vaccines and Therapy 2011 9:1

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