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  1. Research

    Evaluation of the immune responses induced by four targeted DNA vaccines encoding the juvenile liver fluke antigen, cathepsin B in a mouse model

    Liver fluke can infect cattle and sheep, and is also emerging as a human pathogen in developing countries. Cathepsin B (Cat B2) is a major cysteine protease secreted by the juvenile flukes. To enhance the immu...

    Rama Jayaraj, David Piedrafita, Terry Spithill and Peter Smooker

    Genetic Vaccines and Therapy 2012 10:7

    Published on: 31 August 2012

  2. Research

    Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

    Malaria causes immense human morbidity and mortality globally. The plasmodium species vivax and falciparum cause over 75 % clinical malaria cases. Until now, gene-based strategies against malaria have only been a...

    Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera

    Genetic Vaccines and Therapy 2012 10:8

    Published on: 31 August 2012

  3. Research

    A combination of intradermal jet-injection and electroporation overcomes in vivodose restriction of DNA vaccines

    The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacio...

    David Hallengärd, Andreas Bråve, Maria Isaguliants, Pontus Blomberg, Jenny Enger, Richard Stout, Alan King and Britta Wahren

    Genetic Vaccines and Therapy 2012 10:5

    Published on: 8 August 2012

  4. Research

    Structure based sequence analysis & epitope prediction of gp41 HIV1 envelope glycoprotein isolated in Pakistan

    Gp41 is an envelope glycoprotein of human immune deficiency virus (HIV). HIV viral glycoprotein gp41, present in complex with gp120, assists the viral entry into host cell. Over eighty thousands individuals ar...

    Syyada Samra Jafri, Saliha Kiran, Syed Babar Jamal and Masaud Shah

    Genetic Vaccines and Therapy 2012 10:4

    Published on: 20 June 2012

    The Retraction Note to this article has been published in Genetic Vaccines and Therapy 2012 10:10

  5. Research

    An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery

    The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown...

    Ni-Chung Lee, Darin J Falk, Barry J Byrne, Thomas J Conlon, Nathalie Clement, Stacy Porvasnik, Marda L Jorgensen, Mark Potter, Kirsten E Erger, Rachael Watson, Steven C Ghivizzani, Hung-Chuan Chiu, Yin-Hsiu Chien and Wuh-Liang Hwu

    Genetic Vaccines and Therapy 2012 10:3

    Published on: 18 June 2012

  6. Research

    Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

    Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate. While the curre...

    Flávia Helena da Silva, Vanessa Gonçalves Pereira, Eduardo G Yasumura, Lígia Zacchi Tenório, Leonardo Pinto de Carvalho, Bianca Cristina Garcia Lisboa, Priscila Keiko Matsumoto, Roberta Sessa Stilhano, Vivian Y Samoto, Bruno Frederico Aguilar Calegare, Letícia de Campos Brandão, Vânia D’Almeida, Thaís RM Filippo, Marimélia Porcionatto, Leny Toma, Helena Bonciani Nader…

    Genetic Vaccines and Therapy 2012 10:2

    Published on: 20 April 2012

  7. Research

    HCV entry receptors as potential targets for siRNA-based inhibition of HCV

    Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The curre...

    Shah Jahan, Baila Samreen, Saba Khaliq, Bushra Ijaz, Mahwish Khan, Muhammad Hassan Siddique, Waqar Ahmad and Sajida Hassan

    Genetic Vaccines and Therapy 2011 9:15

    Published on: 6 September 2011

  8. Research

    Occult HCV or delayed viral clearance from lymphocytes of Chronic HCV genotype 3 patients after interferon therapy

    A recently discovered occult HCV entity reported by various investigators seems to be highly controversial. Especially, the clinical significance of these findings remains uncertain. For optimal outcome of ant...

    Ambreen G Muazzam, Saleem Qureshi, Atika Mansoor, Lubna Ali, Musarrat Iqbal, Saima Siddiqi, Khalid M Khan and Kehkashan Mazhar

    Genetic Vaccines and Therapy 2011 9:14

    Published on: 6 September 2011

  9. Research

    Establishment of stable Huh-7 cell lines expressing various hepatitis C virus genotype 3a protein: an in-vitro testing system for novel anti-HCV drugs

    Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis which progresses to hepatocellular carcinoma (HCC) afflicting > 170 million people worldwide. HCV 3a is the most common genotype (abo...

    Sadia Butt, Muhammad Idrees, Irshad-ur Rehman, Liaqat Ali, Abrar Hussain, Muhammad Ali, Naveed Ahmed, Sana Saleem and Madiha Fayyaz

    Genetic Vaccines and Therapy 2011 9:12

    Published on: 28 June 2011

  10. Review

    Antiviral drugs against hepatitis C virus

    Hepatitis C virus (HCV) infection is a major worldwide problem causes acute and chronic HCV infection. Current treatment of HCV includes pegylated interferon-α (PEG IFN- α) plus ribavirin (RBV) which has signi...

    Sidra Rehman, Usman A Ashfaq and Tariq Javed

    Genetic Vaccines and Therapy 2011 9:11

    Published on: 23 June 2011

  11. Short report

    A comparison of multiple shRNA expression methods for combinatorial RNAi

    RNAi gene therapies for HIV-1 will likely need to employ multiple shRNAs to counter resistant strains. We evaluated 3 shRNA co-expression methods to determine their suitability for present use; multiple expres...

    Glen J Mcintyre, Allison J Arndt, Kirsten M Gillespie, Wendy M Mak and Gregory C Fanning

    Genetic Vaccines and Therapy 2011 9:9

    Published on: 17 April 2011

  12. Review

    In-vitro model systems to study Hepatitis C Virus

    Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to h...

    Usman Ali Ashfaq, Shaheen N Khan, Zafar Nawaz and Sheikh Riazuddin

    Genetic Vaccines and Therapy 2011 9:7

    Published on: 6 April 2011

  13. Research

    B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis

    Although B cells are important as antigen presenting cells (APC) during the immune response, their role in DNA vaccination models is unknown.

    Luciana P Almeida, Ana PF Trombone, Julio CC Lorenzi, Carolina D Rocha, Thiago Malardo, Isabela C Fontoura, Ana F Gembre, Ricardo LL Silva, Célio L Silva, Ademilson P Castelo and Arlete AM Coelho-Castelo

    Genetic Vaccines and Therapy 2011 9:5

    Published on: 14 March 2011

  14. Research

    In vitro evaluation of a double-stranded self-complementary adeno-associated virus type2 vector in bone marrow stromal cells for bone healing

    Both adenoviral and lentiviral vectors have been successfully used to induce bone repair by over-expression of human bone morphogenetic protein 2 (BMP-2) in primary rat bone marrow stromal cells in pre-clinica...

    Farhang Alaee, Osamu Sugiyama, Mandeep S Virk, Ying Tang, Bing Wang and Jay R Lieberman

    Genetic Vaccines and Therapy 2011 9:4

    Published on: 27 February 2011

  15. Research

    Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells

    Atrial natriuretic peptide (ANP) is an important endogenous hormone that controls inflammation and immunity by acting on dendritic cells (DCs); however, the mechanism remains unclear.

    Weidong Zhang, Xueqin Cao, Dongqing Chen, Jia-wang Wang, Hong Yang, Wenshi Wang, Subhra Mohapatra, Gary Hellermann, Xiaoyuan Kong, Richard F Lockey and Shyam S Mohapatra

    Genetic Vaccines and Therapy 2011 9:3

    Published on: 10 January 2011

  16. Research

    Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors

    The efficacy and biosafety of lentiviral gene transfer is influenced by the design of the vector. To this end, properties of lentiviral vectors can be modified by using cis-acting elements such as the modificatio...

    Nicolas Grandchamp, Dorothée Henriot, Stéphanie Philippe, Lahouari Amar, Suzanna Ursulet, Che Serguera, Jacques Mallet and Chamsy Sarkis

    Genetic Vaccines and Therapy 2011 9:1

    Published on: 4 January 2011

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