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Figure 3 | Genetic Vaccines and Therapy

Figure 3

From: Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

Figure 3

Schematics cleavage-sites by ZFNs along the glycophorin- a gene. This figure graphically illustrates the sites and frequency of ZFN cleavage within the human glycophorin-a gene. Note the presence of ZFNs cleaving at positions approximately 0.02 and 0.92 within the context of the glycophorin-a gene. These are suited for the complete excision of this gene from the genomes of transduced erythroid precursor cells (through non-homologous end-joining), although many more ZFNs with specific-disruptive potential to only specified areas of the same gene, may be constructed. Hits (blue, green, and gold bars) represent targets along the gene (red bars). ZFN hits in the graphic are color-coded based on spacer size (5 bp = Blue; 6 bp = Green; 7 bp = Gold).

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Genetic Vaccines and Therapy

ISSN: 1479-0556