Figure 2From: Prevention of airway inflammation with topical cream containing imiquimod and small interfering RNA for natriuretic peptide receptorNPRA knockout prevents allergic airway inflammation. (A) Knockout of NPRA but not NPRC attenuates airway inflammation. C57BL6 wild type, NPRA-/- and NPRC-/- knockout mice were OVA-sensitized (i.p.) at day zero and day seven and challenged twice with OVA (i.n.). Two days later, mice were sacrificed and lung sections were stained with hematoxylin/eosin. (B) BAL fluids were obtained from WT and NPRA-/- mice and assayed by ELISA for pro-inflammatory cytokines, IL-4, -5 and -6. Results shown are averages of two separate experiments with standard deviations (*, P < 0.05, **, P < 0.01).Back to article page