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Figure 5 | Genetic Vaccines and Therapy

Figure 5

From: Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression

Figure 5

Insertion of intron 7 of the ADA gene results in further enhancement of gene expression. A. SHGI7AL contains intron 7 of the ADA gene in the inverted reverse orientation with respect to the vector elements. 293A, Jurkat, Molt-4 and CEM cells were transduced by SAG, SHGAL or SHGI7AL vectors at MO of 0.1. The MFI of eGFP expression (B) and the percentage of eGFP positive cells (C) were evaluated using FACS analysis.

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Genetic Vaccines and Therapy

ISSN: 1479-0556