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Figure 4 | Genetic Vaccines and Therapy

Figure 4

From: Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen

Figure 4

Core-specific immune response in C57Bl/6 mice receiving 2 (2 × 25 μg), 3 (3 × 25 μg), and 4 (4 × 25 μg) injections of pCMVcoreKozak. Maximal titers of IgG specific to recombinant core and a peptide representing core aa 1–20 (A); T-cell proliferation measured as the stimulation index (SI) in response to HCV core (1–173) and a peptide pool covering aa 23–43 of HCV core (B); cytokine secretion (pg/ml) in response to recombinant HCV core (C). Data are average values for mice assayed at a given time point.

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Genetic Vaccines and Therapy

ISSN: 1479-0556