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Figure 6 | Genetic Vaccines and Therapy

Figure 6

From: Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells

Figure 6

Adoptive transfer of bone marrow-derived DCs (bmDCs) from WT mice increases inflammation in NPRA-/- mice. Eight day-cultured bmDCs generated from WT or NPRA-/- C57BL/6 mice were incubated with OVA for 24 h and injected i.v. into C57BL/6 NPRA-/- mice (5 × 106 DCs/mouse) that had been sensitized and challenged with OVA. On day 8 after adoptive transfer, mice were sacrificed and lung sections were stained with H & E and examined under the microscope for histopathology (A). Lung pathology was also scored according to a 1-5 severity scale (B). Cytokines were measured by cytokine bead array assays in BAL fluid collected from parallel groups of mice (C). Data shown are representative of two experiments with similar results.

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Genetic Vaccines and Therapy

ISSN: 1479-0556