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  1. Content type: Research

    Transfer of genes in utero via the amniotic fluid was shown previously with recombinant adeno-associated viruses (rAAV) to be highly efficient. Expression for over one year was demonstrated using reporter genes. ...

    Authors: Deiadra J Garrett, J Craig Cohen and Janet E Larson

    Citation: Genetic Vaccines and Therapy 2004 2:4

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  2. Content type: Research

    Leber's congenital amaurosis (LCA) is a severe form of retinal dystrophy. Mutations in the RPE65 gene, which is abundantly expressed in retinal pigment epithelial (RPE) cells, account for approximately 10–15% ...

    Authors: Chooi-May Lai, Meaghan JT Yu, Meliha Brankov, Nigel L Barnett, Xiaohuai Zhou, T Michael Redmond, Kristina Narfstrom and P Elizabeth Rakoczy

    Citation: Genetic Vaccines and Therapy 2004 2:3

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  3. Content type: Short paper

    The clinical application of monoclonal antibodies (mAbs) potentially concerns a wide range of diseases including, among others, viral infections, cancer and autoimmune diseases. Although intravenous infusion a...

    Authors: Norma Perez, Pascal Bigey, Daniel Scherman, Olivier Danos, Marc Piechaczyk and Mireia Pelegrin

    Citation: Genetic Vaccines and Therapy 2004 2:2

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  4. Content type: Research

    Tumor cells such as leukemia and lymphoma cells are possible targets for gene therapy. However, previously leukemia and lymphoma cells have been demonstrated to be resistant to most of non-viral gene transfer ...

    Authors: Frank Schakowski, Peter Buttgereit, Martin Mazur, Angela Märten, Björn Schöttker, Marcus Gorschlüter and Ingo GH Schmidt-Wolf

    Citation: Genetic Vaccines and Therapy 2004 2:1

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  5. Content type: Research

    Allergic subjects produce relatively low amounts of IFN-γ, a pleiotropic Th-1 cytokine that downregulates Th2-associated airway inflammation and hyperresponsiveness (AHR), the hallmarks of allergic asthma. Ade...

    Authors: Mukesh Kumar, Xiaoyuan Kong, Aruna K Behera, Gary R Hellermann, Richard F Lockey and Shyam S Mohapatra

    Citation: Genetic Vaccines and Therapy 2003 1:3

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  6. Content type: Review

    DNA vaccination is a relatively recent development in vaccine methodology. It is now possible to undertake a rational step-by-step approach to DNA vaccine design. Strategies may include the incorporation of im...

    Authors: Helen S Garmory, Katherine A Brown and Richard W Titball

    Citation: Genetic Vaccines and Therapy 2003 1:2

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