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  1. Transfer of genes in utero via the amniotic fluid was shown previously with recombinant adeno-associated viruses (rAAV) to be highly efficient. Expression for over one year was demonstrated using reporter genes. ...

    Authors: Deiadra J Garrett, J Craig Cohen and Janet E Larson
    Citation: Genetic Vaccines and Therapy 2004 2:4
  2. Leber's congenital amaurosis (LCA) is a severe form of retinal dystrophy. Mutations in the RPE65 gene, which is abundantly expressed in retinal pigment epithelial (RPE) cells, account for approximately 10–15% ...

    Authors: Chooi-May Lai, Meaghan JT Yu, Meliha Brankov, Nigel L Barnett, Xiaohuai Zhou, T Michael Redmond, Kristina Narfstrom and P Elizabeth Rakoczy
    Citation: Genetic Vaccines and Therapy 2004 2:3
  3. The clinical application of monoclonal antibodies (mAbs) potentially concerns a wide range of diseases including, among others, viral infections, cancer and autoimmune diseases. Although intravenous infusion a...

    Authors: Norma Perez, Pascal Bigey, Daniel Scherman, Olivier Danos, Marc Piechaczyk and Mireia Pelegrin
    Citation: Genetic Vaccines and Therapy 2004 2:2
  4. Tumor cells such as leukemia and lymphoma cells are possible targets for gene therapy. However, previously leukemia and lymphoma cells have been demonstrated to be resistant to most of non-viral gene transfer ...

    Authors: Frank Schakowski, Peter Buttgereit, Martin Mazur, Angela Märten, Björn Schöttker, Marcus Gorschlüter and Ingo GH Schmidt-Wolf
    Citation: Genetic Vaccines and Therapy 2004 2:1
  5. Allergic subjects produce relatively low amounts of IFN-γ, a pleiotropic Th-1 cytokine that downregulates Th2-associated airway inflammation and hyperresponsiveness (AHR), the hallmarks of allergic asthma. Ade...

    Authors: Mukesh Kumar, Xiaoyuan Kong, Aruna K Behera, Gary R Hellermann, Richard F Lockey and Shyam S Mohapatra
    Citation: Genetic Vaccines and Therapy 2003 1:3
  6. DNA vaccination is a relatively recent development in vaccine methodology. It is now possible to undertake a rational step-by-step approach to DNA vaccine design. Strategies may include the incorporation of im...

    Authors: Helen S Garmory, Katherine A Brown and Richard W Titball
    Citation: Genetic Vaccines and Therapy 2003 1:2