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Genetic Vaccines and Therapy

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  1. Content type: Research

    Many strategies have been adopted to unleash the potential of gene therapy for cancer, involving a wide range of therapeutic genes delivered by various methods. Immune therapy has become one of the major strat...

    Authors: Sara A Collins, Alexandra Buhles, Martina F Scallan, Patrick T Harrison, Deirdre M O'Hanlon, Gerald C O'Sullivan and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2010 8:8

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  2. Content type: Research

    Immunization of mice with tumor homogenate after combined treatment with cyclophosphamide (CP) and double-stranded DNA (dsDNA) preparation is effective at inhibition of growth of tumor challenged after the tre...

    Authors: Ekaterina A Alyamkina, Valeriy P Nikolin, Nelly A Popova, Evgenia V Dolgova, Anastasia S Proskurina, Konstantin E Orishchenko, Yaroslav R Efremov, Elena R Chernykh, Alexandr A Ostanin, Sergey V Sidorov, Dmitriy M Ponomarenko, Stanislav N Zagrebelniy, Sergey S Bogachev and Mikhail A Shurdov

    Citation: Genetic Vaccines and Therapy 2010 8:7

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  3. Content type: Research

    Impaired wound healing in diabetes is related to decreased production of growth factors. Hence, gene therapy is considered as promising treatment modality. So far, efforts concentrated on single gene therapy w...

    Authors: Agnieszka Jazwa, Paulina Kucharzewska, Justyna Leja, Anna Zagorska, Aleksandra Sierpniowska, Jacek Stepniewski, Magdalena Kozakowska, Hevidar Taha, Takahiro Ochiya, Rafal Derlacz, Elisa Vahakangas, Seppo Yla-Herttuala, Alicja Jozkowicz and Jozef Dulak

    Citation: Genetic Vaccines and Therapy 2010 8:6

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  4. Content type: Research

    We have previously demonstrated protective efficacy against B. melitensis using formulations of naked DNA vaccines encoding genes ialB and omp25. The present study was undertaken to further understand the immune ...

    Authors: Nicola J Commander, James M Brewer, Brendan W Wren, Stephen A Spencer, Alastair P MacMillan and Judith A Stack

    Citation: Genetic Vaccines and Therapy 2010 8:5

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  5. Content type: Research

    Studies have shown that DNA vaccines can induce protective immunity, which demonstrated the high potential of DNA vaccines as an alternative to inactivated vaccines. Vaccines are frequently formulated with adj...

    Authors: Babak Jalilian, Abdul Rahman Omar, Mohd Hair Bejo, Noorjahan Banu Alitheen, Mehdi Rasoli and Sohkichi Matsumoto

    Citation: Genetic Vaccines and Therapy 2010 8:4

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  6. Content type: Research

    Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little...

    Authors: Amir Ghaemi, Hoorieh Soleimanjahi, Pooria Gill, Zuhair Hassan, Soodeh Razeghi M Jahromi and Farzin Roohvand

    Citation: Genetic Vaccines and Therapy 2010 8:3

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  7. Content type: Research

    Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens.

    Authors: Yaoli Wang, Chunxue Bai, Guansong Wang, Diane Wang, Xiaoming Cheng, Jian Huang, Dongpo Jiang, Guisheng Qian and Xiangdong Wang

    Citation: Genetic Vaccines and Therapy 2010 8:2

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  8. Content type: Research

    Immunological therapies enhance the ability of the immune system to recognise and destroy cancer cells via selective killing mechanisms. DNA vaccines have potential to activate the immune system against specif...

    Authors: Sarfraz Ahmad, Garrett Casey, Paul Sweeney, Mark Tangney and Gerald C O'Sullivan

    Citation: Genetic Vaccines and Therapy 2010 8:1

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  9. Content type: Research

    Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoter...

    Authors: Alice T Trinh, Bret G Ball, Erin Weber, Timothy K Gallaher, Zoya Gluzman-Poltorak, French Anderson and Lena A Basile

    Citation: Genetic Vaccines and Therapy 2009 7:13

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  10. Content type: Research

    When cyclophosphamide and preparations of fragmented exogenous genomic double stranded DNA were administered in sequence, the regressive effect on the tumor was synergic: this combined treatment had a more pro...

    Authors: Ekaterina A Alyamkina, Evgenia V Dolgova, Anastasia S Likhacheva, Vladimir A Rogachev, Tamara E Sebeleva, Valeriy P Nikolin, Nelly A Popova, Konstantin E Orishchenko, Dmitriy N Strunkin, Elena R Chernykh, Stanislav N Zagrebelniy, Sergei S Bogachev and Mikhail A Shurdov

    Citation: Genetic Vaccines and Therapy 2009 7:12

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  11. Content type: Research

    Protein-calorie malnutrition (PCM) is the most common type of malnutrition. PCM leads to immunodeficiency and consequent increased susceptibility to infectious agents. In addition, responses to prophylactic va...

    Authors: Larissa Lumi Watanabe Ishikawa, Thaís Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Nelson Mendes Marra, Paulo Câmara Marques Pereira, Célio Lopes Silva and Alexandrina Sartori

    Citation: Genetic Vaccines and Therapy 2009 7:11

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  12. Content type: Short paper

    In a mouse model for molybdenum cofactor deficiency as an example for an inherited metabolic disease we have determined the dosage of recombinant AAV necessary to rescue the lethal deficiency phenotype. We dem...

    Authors: Rita Hahnewald, Waja Wegner and Jochen Reiss

    Citation: Genetic Vaccines and Therapy 2009 7:9

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  13. Content type: Research

    The use of shRNAs to downregulate the expression of specific genes is now relatively routine in experimentation but still hypothetical for clinical application. A potential therapeutic approach for HIV-1 disea...

    Authors: Saki Shimizu, Masakazu Kamata, Panyamol Kittipongdaja, Kevin N Chen, Sanggu Kim, Shen Pang, Joshua Boyer, F Xiao-Feng Qin, Dong Sung An and Irvin SY Chen

    Citation: Genetic Vaccines and Therapy 2009 7:8

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  14. Content type: Research

    Hepatitis C core protein is an attractive target for HCV vaccine aimed to exterminate HCV infected cells. However, although highly immunogenic in natural infection, core appears to have low immunogenicity in e...

    Authors: Ekaterina Alekseeva, Irina Sominskaya, Dace Skrastina, Irina Egorova, Elizaveta Starodubova, Eriks Kushners, Marija Mihailova, Natalia Petrakova, Ruta Bruvere, Tatyana Kozlovskaya, Maria Isaguliants and Paul Pumpens

    Citation: Genetic Vaccines and Therapy 2009 7:7

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  15. Content type: Short paper

    The most common cause of death of cancer sufferers is through the occurrence of metastases. The metastatic behaviour of tumour cells is regulated by extracellular growth factors such as hepatocyte growth facto...

    Authors: Alexandra Buhles, Sara A Collins, Jan P van Pijkeren, Simon Rajendran, Michelle Miles, Gerald C O'Sullivan, Deirdre M O'Hanlon and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2009 7:5

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  16. Content type: Research

    The use of food-grade lactococci as bacterial carriers to DNA delivery into epithelial cells is a new strategy to develop live oral DNA vaccine. Our goal was to develop a new plasmid, named pValac, for antigen...

    Authors: Valeria Guimarães, Sylvia Innocentin, Jean-Marc Chatel, François Lefèvre, Philippe Langella, Vasco Azevedo and Anderson Miyoshi

    Citation: Genetic Vaccines and Therapy 2009 7:4

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  17. Content type: Research

    Tyrosine kinase inhibitor gefitinib is effective against lung cancer cells carrying mutant epidermal growth factor receptor (EGFR); however, it is not effective against lung cancer carrying normal EGFR. The br...

    Authors: Ming-Derg Lai, Meng-Chi Yen, Chiu-Mei Lin, Cheng-Fen Tu, Chun-Chin Wang, Pei-Shan Lin, Huei-Jiun Yang and Chi-Chen Lin

    Citation: Genetic Vaccines and Therapy 2009 7:2

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  18. Content type: Research

    The delivery of therapeutic genes to the central nervous system (CNS) using viral vectors represents an appealing strategy for the treatment of nerve injury and disorders of the CNS. Important factors determin...

    Authors: Thais Federici, Robert Kutner, Xian-Yang Zhang, Hitoshi Kuroda, Noël Tordo, Nicholas M Boulis and Jakob Reiser

    Citation: Genetic Vaccines and Therapy 2009 7:1

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  19. Content type: Research

    Electroporation is an established technique for enhancing plasmid delivery to many tissues in vivo, including the skin. We have previously demonstrated efficient delivery of plasmid DNA to the skin utilizing a cu...

    Authors: Loree C Heller, Mark J Jaroszeski, Domenico Coppola and Richard Heller

    Citation: Genetic Vaccines and Therapy 2008 6:16

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  20. Content type: Research

    In this research, we developed a novel chimeric HTNV-IL-2-G2 DNA vaccine plasmid by genetically linking IL-2 gene to the G2 segment DNA and tested whether it could be a candidate vaccine. Chimeric gene was fir...

    Authors: Huang Hao, Li Xiu, Zhang Zehua, Jia Min, Hu Hongbo, Wu Zhihong, Zhu Zhenhua, Wan Xiaohong and Huang Hanju

    Citation: Genetic Vaccines and Therapy 2008 6:15

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  21. Content type: Short paper

    The AAV9 capsid displays a high natural affinity for the heart following a single intravenous (IV) administration in both newborn and adult mice. It also results in substantial albeit relatively lower expressi...

    Authors: Christina A Pacak, Yoshihisa Sakai, Bijoy D Thattaliyath, Cathryn S Mah and Barry J Byrne

    Citation: Genetic Vaccines and Therapy 2008 6:13

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