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  1. Content type: Review

    Development of various vaccines for prostate cancer (PCa) is becoming an active research area. PCa vaccines are perceived to have less toxicity compared with the available cytotoxic agents. While various immun...

    Authors: Sarfraz Ahmad, Paul Sweeney, Gerald C Sullivan and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2012 10:9

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  2. Content type: Research

    Malaria causes immense human morbidity and mortality globally. The plasmodium species vivax and falciparum cause over 75 % clinical malaria cases. Until now, gene-based strategies against malaria have only been a...

    Authors: Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera

    Citation: Genetic Vaccines and Therapy 2012 10:8

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  3. Content type: Research

    Liver fluke can infect cattle and sheep, and is also emerging as a human pathogen in developing countries. Cathepsin B (Cat B2) is a major cysteine protease secreted by the juvenile flukes. To enhance the immu...

    Authors: Rama Jayaraj, David Piedrafita, Terry Spithill and Peter Smooker

    Citation: Genetic Vaccines and Therapy 2012 10:7

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  4. Content type: Research

    The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacio...

    Authors: David Hallengärd, Andreas Bråve, Maria Isaguliants, Pontus Blomberg, Jenny Enger, Richard Stout, Alan King and Britta Wahren

    Citation: Genetic Vaccines and Therapy 2012 10:5

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  5. Content type: Research

    Gp41 is an envelope glycoprotein of human immune deficiency virus (HIV). HIV viral glycoprotein gp41, present in complex with gp120, assists the viral entry into host cell. Over eighty thousands individuals ar...

    Authors: Syyada Samra Jafri, Saliha Kiran, Syed Babar Jamal and Masaud Shah

    Citation: Genetic Vaccines and Therapy 2012 10:4

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    The Retraction Note to this article has been published in Genetic Vaccines and Therapy 2012 10:10

  6. Content type: Research

    The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown...

    Authors: Ni-Chung Lee, Darin J Falk, Barry J Byrne, Thomas J Conlon, Nathalie Clement, Stacy Porvasnik, Marda L Jorgensen, Mark Potter, Kirsten E Erger, Rachael Watson, Steven C Ghivizzani, Hung-Chuan Chiu, Yin-Hsiu Chien and Wuh-Liang Hwu

    Citation: Genetic Vaccines and Therapy 2012 10:3

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  7. Content type: Research

    Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate. While the curre...

    Authors: Flávia Helena da Silva, Vanessa Gonçalves Pereira, Eduardo G Yasumura, Lígia Zacchi Tenório, Leonardo Pinto de Carvalho, Bianca Cristina Garcia Lisboa, Priscila Keiko Matsumoto, Roberta Sessa Stilhano, Vivian Y Samoto, Bruno Frederico Aguilar Calegare, Letícia de Campos Brandão, Vânia D’Almeida, Thaís RM Filippo, Marimélia Porcionatto, Leny Toma, Helena Bonciani Nader…

    Citation: Genetic Vaccines and Therapy 2012 10:2

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  8. Content type: Research

    Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The curre...

    Authors: Shah Jahan, Baila Samreen, Saba Khaliq, Bushra Ijaz, Mahwish Khan, Muhammad Hassan Siddique, Waqar Ahmad and Sajida Hassan

    Citation: Genetic Vaccines and Therapy 2011 9:15

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  9. Content type: Research

    A recently discovered occult HCV entity reported by various investigators seems to be highly controversial. Especially, the clinical significance of these findings remains uncertain. For optimal outcome of ant...

    Authors: Ambreen G Muazzam, Saleem Qureshi, Atika Mansoor, Lubna Ali, Musarrat Iqbal, Saima Siddiqi, Khalid M Khan and Kehkashan Mazhar

    Citation: Genetic Vaccines and Therapy 2011 9:14

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  10. Content type: Research

    Peptide/DNA complexes have great potential as non-viral methods for gene delivery. Despite promising results for peptide-mediated gene delivery technology, an effective systemic peptide-based gene delivery sys...

    Authors: Jung Gyu Woo, Na Young Kim, Jai Myung Yang and Sungho Shin

    Citation: Genetic Vaccines and Therapy 2011 9:13

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  11. Content type: Research

    Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis which progresses to hepatocellular carcinoma (HCC) afflicting > 170 million people worldwide. HCV 3a is the most common genotype (abo...

    Authors: Sadia Butt, Muhammad Idrees, Irshad-ur Rehman, Liaqat Ali, Abrar Hussain, Muhammad Ali, Naveed Ahmed, Sana Saleem and Madiha Fayyaz

    Citation: Genetic Vaccines and Therapy 2011 9:12

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  12. Content type: Review

    Hepatitis C virus (HCV) infection is a major worldwide problem causes acute and chronic HCV infection. Current treatment of HCV includes pegylated interferon-α (PEG IFN- α) plus ribavirin (RBV) which has signi...

    Authors: Sidra Rehman, Usman A Ashfaq and Tariq Javed

    Citation: Genetic Vaccines and Therapy 2011 9:11

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  13. Content type: Short report

    RNAi gene therapies for HIV-1 will likely need to employ multiple shRNAs to counter resistant strains. We evaluated 3 shRNA co-expression methods to determine their suitability for present use; multiple expres...

    Authors: Glen J Mcintyre, Allison J Arndt, Kirsten M Gillespie, Wendy M Mak and Gregory C Fanning

    Citation: Genetic Vaccines and Therapy 2011 9:9

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  14. Content type: Research

    The envelope glycoprotein of lymphocytic choriomeningitis virus (LCMV) can efficiently pseudotype lentiviral vectors. Some strains of LCMV exploit high affinity interactions with α-dystroglycan (α-DG) to bind ...

    Authors: Douglas E Dylla, Litao Xie, Daniel E Michele, Stefan Kunz and Paul B McCray Jr

    Citation: Genetic Vaccines and Therapy 2011 9:8

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  15. Content type: Review

    Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to h...

    Authors: Usman Ali Ashfaq, Shaheen N Khan, Zafar Nawaz and Sheikh Riazuddin

    Citation: Genetic Vaccines and Therapy 2011 9:7

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  16. Content type: Research

    Although B cells are important as antigen presenting cells (APC) during the immune response, their role in DNA vaccination models is unknown.

    Authors: Luciana P Almeida, Ana PF Trombone, Julio CC Lorenzi, Carolina D Rocha, Thiago Malardo, Isabela C Fontoura, Ana F Gembre, Ricardo LL Silva, Célio L Silva, Ademilson P Castelo and Arlete AM Coelho-Castelo

    Citation: Genetic Vaccines and Therapy 2011 9:5

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  17. Content type: Research

    Both adenoviral and lentiviral vectors have been successfully used to induce bone repair by over-expression of human bone morphogenetic protein 2 (BMP-2) in primary rat bone marrow stromal cells in pre-clinica...

    Authors: Farhang Alaee, Osamu Sugiyama, Mandeep S Virk, Ying Tang, Bing Wang and Jay R Lieberman

    Citation: Genetic Vaccines and Therapy 2011 9:4

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  18. Content type: Research

    Atrial natriuretic peptide (ANP) is an important endogenous hormone that controls inflammation and immunity by acting on dendritic cells (DCs); however, the mechanism remains unclear.

    Authors: Weidong Zhang, Xueqin Cao, Dongqing Chen, Jia-wang Wang, Hong Yang, Wenshi Wang, Subhra Mohapatra, Gary Hellermann, Xiaoyuan Kong, Richard F Lockey and Shyam S Mohapatra

    Citation: Genetic Vaccines and Therapy 2011 9:3

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  19. Content type: Research

    The efficacy and biosafety of lentiviral gene transfer is influenced by the design of the vector. To this end, properties of lentiviral vectors can be modified by using cis-acting elements such as the modificatio...

    Authors: Nicolas Grandchamp, Dorothée Henriot, Stéphanie Philippe, Lahouari Amar, Suzanna Ursulet, Che Serguera, Jacques Mallet and Chamsy Sarkis

    Citation: Genetic Vaccines and Therapy 2011 9:1

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  20. Content type: Research

    Many strategies have been adopted to unleash the potential of gene therapy for cancer, involving a wide range of therapeutic genes delivered by various methods. Immune therapy has become one of the major strat...

    Authors: Sara A Collins, Alexandra Buhles, Martina F Scallan, Patrick T Harrison, Deirdre M O'Hanlon, Gerald C O'Sullivan and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2010 8:8

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  21. Content type: Research

    Immunization of mice with tumor homogenate after combined treatment with cyclophosphamide (CP) and double-stranded DNA (dsDNA) preparation is effective at inhibition of growth of tumor challenged after the tre...

    Authors: Ekaterina A Alyamkina, Valeriy P Nikolin, Nelly A Popova, Evgenia V Dolgova, Anastasia S Proskurina, Konstantin E Orishchenko, Yaroslav R Efremov, Elena R Chernykh, Alexandr A Ostanin, Sergey V Sidorov, Dmitriy M Ponomarenko, Stanislav N Zagrebelniy, Sergey S Bogachev and Mikhail A Shurdov

    Citation: Genetic Vaccines and Therapy 2010 8:7

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  22. Content type: Research

    Impaired wound healing in diabetes is related to decreased production of growth factors. Hence, gene therapy is considered as promising treatment modality. So far, efforts concentrated on single gene therapy w...

    Authors: Agnieszka Jazwa, Paulina Kucharzewska, Justyna Leja, Anna Zagorska, Aleksandra Sierpniowska, Jacek Stepniewski, Magdalena Kozakowska, Hevidar Taha, Takahiro Ochiya, Rafal Derlacz, Elisa Vahakangas, Seppo Yla-Herttuala, Alicja Jozkowicz and Jozef Dulak

    Citation: Genetic Vaccines and Therapy 2010 8:6

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  23. Content type: Research

    We have previously demonstrated protective efficacy against B. melitensis using formulations of naked DNA vaccines encoding genes ialB and omp25. The present study was undertaken to further understand the immune ...

    Authors: Nicola J Commander, James M Brewer, Brendan W Wren, Stephen A Spencer, Alastair P MacMillan and Judith A Stack

    Citation: Genetic Vaccines and Therapy 2010 8:5

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  24. Content type: Research

    Studies have shown that DNA vaccines can induce protective immunity, which demonstrated the high potential of DNA vaccines as an alternative to inactivated vaccines. Vaccines are frequently formulated with adj...

    Authors: Babak Jalilian, Abdul Rahman Omar, Mohd Hair Bejo, Noorjahan Banu Alitheen, Mehdi Rasoli and Sohkichi Matsumoto

    Citation: Genetic Vaccines and Therapy 2010 8:4

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  25. Content type: Research

    Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little...

    Authors: Amir Ghaemi, Hoorieh Soleimanjahi, Pooria Gill, Zuhair Hassan, Soodeh Razeghi M Jahromi and Farzin Roohvand

    Citation: Genetic Vaccines and Therapy 2010 8:3

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  26. Content type: Research

    Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens.

    Authors: Yaoli Wang, Chunxue Bai, Guansong Wang, Diane Wang, Xiaoming Cheng, Jian Huang, Dongpo Jiang, Guisheng Qian and Xiangdong Wang

    Citation: Genetic Vaccines and Therapy 2010 8:2

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  27. Content type: Research

    Immunological therapies enhance the ability of the immune system to recognise and destroy cancer cells via selective killing mechanisms. DNA vaccines have potential to activate the immune system against specif...

    Authors: Sarfraz Ahmad, Garrett Casey, Paul Sweeney, Mark Tangney and Gerald C O'Sullivan

    Citation: Genetic Vaccines and Therapy 2010 8:1

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  28. Content type: Research

    Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoter...

    Authors: Alice T Trinh, Bret G Ball, Erin Weber, Timothy K Gallaher, Zoya Gluzman-Poltorak, French Anderson and Lena A Basile

    Citation: Genetic Vaccines and Therapy 2009 7:13

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  29. Content type: Research

    When cyclophosphamide and preparations of fragmented exogenous genomic double stranded DNA were administered in sequence, the regressive effect on the tumor was synergic: this combined treatment had a more pro...

    Authors: Ekaterina A Alyamkina, Evgenia V Dolgova, Anastasia S Likhacheva, Vladimir A Rogachev, Tamara E Sebeleva, Valeriy P Nikolin, Nelly A Popova, Konstantin E Orishchenko, Dmitriy N Strunkin, Elena R Chernykh, Stanislav N Zagrebelniy, Sergei S Bogachev and Mikhail A Shurdov

    Citation: Genetic Vaccines and Therapy 2009 7:12

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  30. Content type: Research

    Protein-calorie malnutrition (PCM) is the most common type of malnutrition. PCM leads to immunodeficiency and consequent increased susceptibility to infectious agents. In addition, responses to prophylactic va...

    Authors: Larissa Lumi Watanabe Ishikawa, Thaís Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Nelson Mendes Marra, Paulo Câmara Marques Pereira, Célio Lopes Silva and Alexandrina Sartori

    Citation: Genetic Vaccines and Therapy 2009 7:11

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  31. Content type: Short paper

    In a mouse model for molybdenum cofactor deficiency as an example for an inherited metabolic disease we have determined the dosage of recombinant AAV necessary to rescue the lethal deficiency phenotype. We dem...

    Authors: Rita Hahnewald, Waja Wegner and Jochen Reiss

    Citation: Genetic Vaccines and Therapy 2009 7:9

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  32. Content type: Research

    The use of shRNAs to downregulate the expression of specific genes is now relatively routine in experimentation but still hypothetical for clinical application. A potential therapeutic approach for HIV-1 disea...

    Authors: Saki Shimizu, Masakazu Kamata, Panyamol Kittipongdaja, Kevin N Chen, Sanggu Kim, Shen Pang, Joshua Boyer, F Xiao-Feng Qin, Dong Sung An and Irvin SY Chen

    Citation: Genetic Vaccines and Therapy 2009 7:8

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  33. Content type: Research

    Hepatitis C core protein is an attractive target for HCV vaccine aimed to exterminate HCV infected cells. However, although highly immunogenic in natural infection, core appears to have low immunogenicity in e...

    Authors: Ekaterina Alekseeva, Irina Sominskaya, Dace Skrastina, Irina Egorova, Elizaveta Starodubova, Eriks Kushners, Marija Mihailova, Natalia Petrakova, Ruta Bruvere, Tatyana Kozlovskaya, Maria Isaguliants and Paul Pumpens

    Citation: Genetic Vaccines and Therapy 2009 7:7

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  34. Content type: Short paper

    The most common cause of death of cancer sufferers is through the occurrence of metastases. The metastatic behaviour of tumour cells is regulated by extracellular growth factors such as hepatocyte growth facto...

    Authors: Alexandra Buhles, Sara A Collins, Jan P van Pijkeren, Simon Rajendran, Michelle Miles, Gerald C O'Sullivan, Deirdre M O'Hanlon and Mark Tangney

    Citation: Genetic Vaccines and Therapy 2009 7:5

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  35. Content type: Research

    The use of food-grade lactococci as bacterial carriers to DNA delivery into epithelial cells is a new strategy to develop live oral DNA vaccine. Our goal was to develop a new plasmid, named pValac, for antigen...

    Authors: Valeria Guimarães, Sylvia Innocentin, Jean-Marc Chatel, François Lefèvre, Philippe Langella, Vasco Azevedo and Anderson Miyoshi

    Citation: Genetic Vaccines and Therapy 2009 7:4

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  36. Content type: Research

    Tyrosine kinase inhibitor gefitinib is effective against lung cancer cells carrying mutant epidermal growth factor receptor (EGFR); however, it is not effective against lung cancer carrying normal EGFR. The br...

    Authors: Ming-Derg Lai, Meng-Chi Yen, Chiu-Mei Lin, Cheng-Fen Tu, Chun-Chin Wang, Pei-Shan Lin, Huei-Jiun Yang and Chi-Chen Lin

    Citation: Genetic Vaccines and Therapy 2009 7:2

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  37. Content type: Research

    The delivery of therapeutic genes to the central nervous system (CNS) using viral vectors represents an appealing strategy for the treatment of nerve injury and disorders of the CNS. Important factors determin...

    Authors: Thais Federici, Robert Kutner, Xian-Yang Zhang, Hitoshi Kuroda, Noël Tordo, Nicholas M Boulis and Jakob Reiser

    Citation: Genetic Vaccines and Therapy 2009 7:1

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  38. Content type: Research

    Electroporation is an established technique for enhancing plasmid delivery to many tissues in vivo, including the skin. We have previously demonstrated efficient delivery of plasmid DNA to the skin utilizing a cu...

    Authors: Loree C Heller, Mark J Jaroszeski, Domenico Coppola and Richard Heller

    Citation: Genetic Vaccines and Therapy 2008 6:16

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  39. Content type: Research

    In this research, we developed a novel chimeric HTNV-IL-2-G2 DNA vaccine plasmid by genetically linking IL-2 gene to the G2 segment DNA and tested whether it could be a candidate vaccine. Chimeric gene was fir...

    Authors: Huang Hao, Li Xiu, Zhang Zehua, Jia Min, Hu Hongbo, Wu Zhihong, Zhu Zhenhua, Wan Xiaohong and Huang Hanju

    Citation: Genetic Vaccines and Therapy 2008 6:15

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  40. Content type: Short paper

    The AAV9 capsid displays a high natural affinity for the heart following a single intravenous (IV) administration in both newborn and adult mice. It also results in substantial albeit relatively lower expressi...

    Authors: Christina A Pacak, Yoshihisa Sakai, Bijoy D Thattaliyath, Cathryn S Mah and Barry J Byrne

    Citation: Genetic Vaccines and Therapy 2008 6:13

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